Sex Differences in Long-term Opioid Use
نویسندگان
چکیده
منابع مشابه
Sex differences in opioid antinociception.
Previous studies indicate that mu opioid agonists such as morphine may produce greater antinociception in male than in female rodents. The present study was designed to investigate the generality of this finding across dose, time and type of opioid agonist. In adult female and male Sprague-Dawley rats, time-effect curves were obtained for vehicle and three doses each of the mu agonists fentanyl...
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In recent years it has become apparent that sex is a major factor involved in modulating the pharmacological effects of exogenous opioids. The kappa opioid receptor (KOPR) system is a potential therapeutic target for pain, mood disorders and addiction. In humans mixed KOPR/MOPR ligands have been found to produce greater analgesia in women than men. In contrast, in animals, selective KOPR agonis...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 2012
ISSN: 0003-9926
DOI: 10.1001/archinternmed.2011.1741